Ali Eroglu, PhD, D.V.M.
Molecular Oncology Program
Address: CA 2004
1120 15th Street
Augusta, GA 30912
Office: (706) 721-7595
As the living cell is being established as a therapeutic tool in medicine, generation and appropriate preservation of such cells are fundamental to the future of emerging cell therapies. Our research interests include both generation of pluripotent stem cells by reprogramming and development of reliable cell cryopreservation techniques. We are particularly interested in developing a clinically dependable oocyte cryopreservation technique for young women undergoing cancer therapy. To this end, we are using a strategy based on survival schemes in nature. Further, we have ongoing studies on epigenetic birth defects..
Karlsson, J.O.M., Younis, A.I., Chan, A.W., Gould, K.G., Eroglu, A. (2009) Permeability of the Rhesus Monkey Oocyte Membrane to Water and Common Cryoprotectants. Mol Reprod Dev 76, 332-333.
Eroglu, A., Bailey, S.E., Toner, M., Toth, T.L. (2009) Successful cryopreservation of mouse oocytes by using low concentrations of trehalose and dimethylsulfoxide. Biology of Reproduction 80, 70-78.
Keskintepe, L.., Norris, K., Pacholczyk, G., Morris Dederscheck, S., and Eroglu, A. (2007) Derivation and Comparison of C57BL/6 Embryonic Stem Cells to a Widely Used 129 Embryonic Stem Cell Line. Transgenic Res 16, 751-758 .
Eroglu, A., Toner, M., and Toth, T.L. (2002) Beneficial effect of microinjected trehalose on the cryosurvival of human oocytes. Fertil. Steril. 77:152-158.
Eroglu, A., Russo, M., Bieganski, R., Fowler, A., Cheley, S., Bayley, H., and Toner, M. (2000)Intracellular trehalose improves the survival of cryopreserved mammalian cells. Nature Biotech. 18:163-167