Research Interests

The research in Dr. Carroll's laboratory includes...

Research Projects

Dr. Carroll’s research includes:

1) Autologous Stem Cell Trial in Children with Cerebral Palsy

We will use umbilical cord blood that has been saved from the child's birth. Children whose parents have stored their cord blood and who have been diagnosed has having cerebral palsy will be eligible for the study. The study will be a controlled trial with the children receiving the transplant at different intervals, in order to determine if the treatment is effective. The study has been approved by the FDA. The study is supported by the Cord Blood Registry and Associazione per l'Assistenza ai Figli Inabili dei Dipendenti, an Italian organization.

2) Preclinical Evaluation of MultiStem

We are using a brain injury model in neonatal rats in order to test the benefit of MultiStem cells, a patented type of adult stem cell. This type of cell shows great promise in the animals, and we are currently collecting data to demonstrate that the cell are suitable for use in children with brain injuries. We believe the cells will promote the regeneration of injured brain. This study is supported by NIH funding and the biotech company, Athersys.

3) Induced Pluripotent Stem Cells for Chronic Brain Injury in Young Mice

This study is designed to examine the possible benefit of stem cells in a long term model for cerebral palsy.  This study is supported by Associazone Figli Inabili Banca d’Italia.

4) Effect of Oligomers on Cellular Migration in Neonatal Hypoxic-Ischemic Injury – Mechanisms of Regeneration

In this study we examine intrinsic mechanisms of brain cell regeneration. 

 

Lab Personnel

James E. Carroll, M.D., Principal Investigator

Muhammed Ali, Ph.D., Post Doc

Hereward Wimborne, B.S., Research Assistant