Cardiovascular research is a strong and growing area of research in our Department and at GHSU at large. There are currently five principal investigators based in Pharmacology and Toxicology (Drs. Barman, Caldwell, Johnson, Rudic, Su, and White as well as Drs. Romero, and Kondrikov investigating questions involving cardiovascular sciences. We are currently recruiting another faculty investigator. Our studies are directed toward cardiac and vascular disorders including heart failure, myocardial infarction, systemic and pulmonary hypertension, estrogen-related cardiovascular disorders, and diabetes. Focal areas of investigation include mechanisms of vascular endothelial dysfunction, mitochrondrial dysfunction in cardiac myocytes, and circadian regulation of vascular function. In addition to our Departmental faculty, there are cardiovascular investigators in the Department of Physiology, Vascular Biology Center, Georgia Prevention Institute and the Division of Cardiology. Collaborations among these groups abound. Some of the postdoctoral and graduate trainees are being supported by Cardiovascular Sciences training grants awarded to GHSU. Our seminar programs bring leaders in Cardiovascular Science from around the country and the world. Weekly journal clubs provide faculty, students and post-docs the occasion to discuss cutting edge cardiovascular research.